Evidence Generation

Providing the Evidence you need

Convince your audience with a compelling product story

Evidence Generation is crucial for developing an outstanding Value Proposition of your product. It provides excellent arguments to explain the benefits your product delivers to your audiences.

However, when demonstrating your product's value to different audiences, it becomes clear that each of them has a different perspective and expectation of value, which need to be addressed.

Hence, a comprehensive value proposition addresses the following stakeholders:

Once all necessary data are collected and in order to satisfy the audience addressed in a value proposition, it is crucial to find answers to the following questions:

We will be happy to help you demonstrate the true value of your product to your target audience, by offering the following services:

Systematic Literature Review

As an integral part of evidence generation, a Systematic Literature Review (SLR) helps answer specific health-related and health economic questions, needed to support a Product Value Proposition, before they are presented to key decision makers.

Conducted as an umbrella review, the SLR incorporates and analyzes data across multiple reviews and meta-analysis.

We can help you explore the following areas carrying out a SLR:

Epidemiology
Clinical & patient pathways and Standard of Care (SoC)
Cost comparison with SoC
Humanistic and economic burden of disease
Gap analysis.

HEOR

As governments and payers struggle continuously how to ensure the best possible health-related outcomes at affordable costs, Health Economics Outcomes Research (HEOR) has become an area of increasing interest.

In a world where therapeutic interventions need to be selected among multiple treatment options, the health-related benefits and economic impact of all alternatives may differ significantly.

HEOR supports clinicians, governments, payers, patients and politicians in their decision making process, while adequately comparing clinical benefits and costs of therapeutic interventions.

We can support you leverage your HEOR story with:

Budget Impact Model
Cost-Minimization analysis
Local adaptation of Cost-Effectiveness models
Cost-Benefit analysis
Expert validation

Real World Evidence (RWE)

Real World Evidence is a powerful resource to understand the efficacy, safety and cost of existing and potential new treatment options.

Clinical trials like randomized controlled trials (RCTs) may provide valuable clinical data, collected under strictly controlled conditions and with clearly defined patient populations.

As valuable as these data may be, they are far from reflecting realistic conditions in healthcare-providing institutions.

Payers and reimbursement bodies are therefore increasingly interested to learn about health-related outcomes and budgetary impacts of medicines in real-world settings. Learn more

Several data sources can be used to collect RWE data:

Patient records
Registries
Claims data
Patient surveys
Observational study data
Post-marketing study data (Phase IV).

Portfolio & Asset Management

Pharma portfolio and asset management refers to the strategic process of selecting, prioritizing and optimizing a company's portfolio with products to maximize returns and minimize risks.

Portfolio optimization involves continually evaluating and adjusting your portfolio, based on changing market conditions and new scientific insights. It may involve divesting underperforming assets, acquiring promising new compounds or licensing external innovations to enhance the portfolio's value.

We can help you develop and implement your portfolio management strategy by:

focusing on therapeutic areas
searching for potential partners (startups, research institutions, pharmaceutical companies, etc.) through licensing agreements and partnerships
following a product's post-launch lifecycle and assessing market dynamics and performances, in order to further invest to maximize value or to divest.
planning future scenarios and forecasting.

Competitor analysis & Benchmarking

Competitor analysis and Benchmarking can help pharma companies understand the market landscape and identify gaps and niches, develop effective market access strategies and positioning, and anticipate future moves of competitors and trends in the market.

It can help enhance product development, innovation capabilities, as well as mitigate risks and avoid costly mistakes.

Squares can provide you a thorough competitor analysis, which includes the following:

Identification of the competitors and key metrics to be analyzed
Data collection, either quantitative or qualitative, and verification
SWOT analysis
Development of a competitor strategy and action plan.